S0488 The Effect of Prucalopride on Abdominal Bloating in Patients With Chronic Idiopathic Constipation Who Had Moderate to Very Severe Abdominal Bloating at Baseline
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چکیده
منابع مشابه
Linaclotide in Chronic Idiopathic Constipation Patients with Moderate to Severe Abdominal Bloating: A Randomized, Controlled Trial
BACKGROUND Abdominal bloating is a common and bothersome symptom of chronic idiopathic constipation. The objective of this trial was to evaluate the efficacy and safety of linaclotide in patients with chronic idiopathic constipation and concomitant moderate-to-severe abdominal bloating. METHODS This Phase 3b, randomized, double-blind, placebo-controlled clinical trial randomized patients to o...
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Ten to 25% of healthy persons experience bloating. It is particularly common in persons with the irritable bowel syndrome and constipation. While the cause of bloating remains unknown old explanations such as a excessive intestinal gas, exaggerated lumbar lordosis and psychiatric problems have been disproved. New suggestions include recent weight gain, weak or inappropriately relaxed abdominal ...
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BACKGROUND Lubiprostone (8 μg b.d.) received US Food and Drug Administration (FDA) approval in 2008 for the treatment of constipation-predominant irritable bowel syndrome (IBS-C) in women aged ≥18 years. In 2012, the FDA issued new guidance for IBS-C clinical trials, recommending a composite endpoint incorporating both abdominal pain and stool frequency. AIM In a post hoc analysis, similar cr...
متن کاملAbdominal Bloating: a Mysterious Symptom
Excessive gas (flatulence), frequent burping (eructation), and abdominal rumbling (borborygmi) are some of the other bloating-related symptoms that may be present in some patients. In a US household survey, 16% of the population reported having bloating or distension, and three quarters of them found it to be moderate to severe. Almost half (43%) reported using a medication for it. Not surprisi...
متن کاملAbdominal Bloating: Pathophysiology and Treatment
Abdominal bloating is a very common and troublesome symptom of all ages, but it has not been fully understood to date. Bloating is usually associated with functional gastrointestinal disorders or organic diseases, but it may also appear alone. The pathophysiology of bloating remains ambiguous, although some evidences support the potential mechanisms, including gut hypersensitivity, impaired gas...
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ژورنال
عنوان ژورنال: American Journal of Gastroenterology
سال: 2020
ISSN: 0002-9270,1572-0241
DOI: 10.14309/01.ajg.0000704000.19511.12